Sickle-Cell Trait Did Not Independently Elevate CHD Risk in Meta-Analysis

African Americans with sickle-cell trait (SCT), that is, who are heterozygous for the sickle-cell gene variant, don't as a result necessarily have an elevated risk of myocardial infarction (MI) or other cardiovascular (CV) events, a meta-analysis of observational studies suggests.

The research argues against CV disease as an independent cause of the excess risk of sudden death often associated with SCT, although these studies don't rule out an interaction between SCT and CV events in the presence of other risk factors, the authors say.

From the Medscape


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